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Related Experiment Video

Updated: Jul 5, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
08:26

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

Universal cell labelling with anionic magnetic nanoparticles.

Claire Wilhelm1, Florence Gazeau

  • 1Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057 CNRS et Université Paris-Diderot, Paris, France. claire.wilhelm@univ-paris-diderot.fr

Biomaterials
|May 6, 2008
PubMed
Summary
This summary is machine-generated.

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Anionic magnetic nanoparticles (AMNPs) offer a versatile, non-specific cell labeling method. This approach enables efficient magnetic cell tracking, manipulation, and MRI detection across diverse cell types.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cell Biology

Background:

  • Magnetic labeling of living cells is crucial for applications like cell tracking and manipulation.
  • Existing methods may lack specificity or broad applicability across different cell types.

Purpose of the Study:

  • To develop and characterize a non-specific magnetic labeling method using anionic magnetic nanoparticles (AMNPs).
  • To evaluate the labeling mechanism, uptake efficiency, and biocompatibility of AMNPs across various cell types.
  • To assess the utility of AMNP labeling for MRI detection and cell manipulation.

Main Methods:

  • Utilized anionic magnetic nanoparticles (AMNPs) for cell labeling.
  • Investigated electrostatic adsorption to cell membranes followed by endocytosis.

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Last Updated: Jul 5, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
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Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

Antibody Labeling with Fluorescent Dyes Using Magnetic Protein A and Protein G Beads
06:48

Antibody Labeling with Fluorescent Dyes Using Magnetic Protein A and Protein G Beads

Published on: September 15, 2016

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06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

  • Assessed labeling efficiency and biocompatibility in 14 different cell types (adult, progenitor, immune, tumor cells).
  • Developed a predictive model for cell/nanoparticle interactions and uptake.

    • Main Results:

    • A single model accurately described cell/nanoparticle interactions and predicted uptake efficiency across all tested cell types.
    • AMNPs demonstrated efficient internalization via endosomes following initial electrostatic adsorption.
    • Biocompatibility and functional impact were evaluated in vitro and in vivo, considering cellular specificities.
    • The AMNP label provided sufficient magnetization for MRI detection and manipulation.

    Conclusions:

    • Anionic magnetic nanoparticles provide a robust and broadly applicable method for magnetic cell labeling.
    • The developed labeling strategy is effective across a wide range of cell types, facilitating diverse biomedical applications.
    • AMNP labeling supports advanced applications including MRI tracking and precise cell manipulation.