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A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury
Published on: March 31, 2023
[Stroke due to spontaneous calcified cerebral embolus as presenting feature of calcified aortic stenosis]
J-M Bugnicourt1, B Bonnaire, L Lepage
1Service de neurologie, CHU d'Amiens, 80054 Amiens cedex 1, France. bugnicourt.jean-marc@chu-amiens.fr
Insights
A rare calcified cerebral embolus from aortic valve disease caused an ischemic stroke in an 81-year-old man. This case highlights a potential, though uncommon, link between aortic valve calcification and stroke risk.
Area of Science:
- Neurology
- Cardiology
- Vascular Medicine
Background:
- Calcified emboli are rare causes of ischemic stroke.
- Aortic valve calcification is typically not considered a primary stroke risk factor unless severe.
Observation:
- An 81-year-old male with hypertension, hyperlipidemia, and renal impairment presented with hemiparesis and aphasia.
- Head CT revealed a calcified embolus in the left anterior cerebral artery and a left paracentral lobule infarct.
- Transesophageal echocardiography showed a sclerotic aortic valve.
Findings:
- The patient experienced a stroke attributed to a calcified cerebral embolus originating from the aortic valve.
- This represents a rare instance of calcified embolus in the anterior cerebral artery territory.
- Renal failure was noted as a contributing factor to cardiovascular disease development.
Implications:
- This case suggests a potential, albeit rare, association between aortic valve calcification and ischemic stroke.
- Further investigation may be warranted for aortic valve calcification as a stroke risk marker, especially in patients with comorbidities.
- Understanding rare embolic sources is crucial for comprehensive stroke prevention strategies.
Abstract:
We report a case of calcified aortic stenosis revealed by an ischemic stroke. An 81-year-old man with hyperlipidemia, hypertension and renal function impairment presented with acute onset of right-sided hemiparesis and aphasia. Head CT scan revealed a rounded calcified high-density mass within the distal segment of the left anterior cerebral artery, consistent with a calcified cerebral embolus, and an infarct in the left paracentral lobule. Transesophageal echocardiography demonstrated a sclerotic aortic valve. The patient was discharged from hospital on aspirin and atorvastatin, and the outcome was favorable. Calcified embolus remains a rare event and it has been not yet reported in the territory of anterior cerebral artery. It may be observed in aortic and mitral valve diseases, calcified plaques of the internal carotid artery and aortic arch. Renal failure promotes their development and is the cause of cardiovascular diseases. To date, aortic valve calcification is not considered as a marker of stroke risk, except when associated with severe stenosis or left ventricular hypertrophy.
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