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Related Experiment Video

Updated: Jul 5, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Translating basic research into clinical rheumatology.

D van der Woude¹, T W J Huizinga

¹Leiden University Medical Center, Department of Rheumatology, Albinusdreef 2, 2300 RC Leiden, The Netherlands. dvanderwoude@lumc.nl <dvanderwoude@lumc.nl>

Best Practice & Research. Clinical Rheumatology

|May 6, 2008

Summary

Basic research and clinical observations have advanced rheumatoid arthritis (RA) understanding, leading to targeted therapies. Further research is needed to optimize treatment combinations for maximum patient benefit.

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Last Updated: Jul 5, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Area of Science:

Rheumatology
Immunology
Pathophysiology

Background:

Rheumatoid arthritis (RA) pathophysiology is increasingly understood through integrated basic research and clinical data.
Key cellular and soluble mediators driving RA progression at different disease stages have been identified.

Purpose of the Study:

To present a multistage model of RA pathophysiology.
To highlight the impact of newly developed targeted therapeutic agents.
To identify remaining challenges in optimizing RA treatment.

Main Methods:

Integration of findings from basic scientific research.
Analysis of precise clinical observations of rheumatoid arthritis disease course.
Review of current and emerging targeted therapeutic agents.

Main Results:

A multistage model for RA pathophysiology has been developed.
Targeted therapies are now available, intervening at multiple pathogenic levels.
Significant patient improvements have been observed with current treatments.

Conclusions:

New therapeutic agents offer substantial benefits for rheumatoid arthritis patients.
Optimal timing and combination strategies for novel RA therapies require further investigation.
Collaborative efforts between basic research and clinical trials are crucial for maximizing treatment potential.