Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
The Muscular System01:18

The Muscular System

The muscular system is essential to the body's overall structure and function, playing a crucial role in movement, stability, and internal processes. It consists of three distinct types of muscle tissue: the skeletal, the smooth, and the cardiac muscles.
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The clinical profile of systemic sclerosis without a 'scleroderma pattern' at nailfold capillaroscopy: results from the multicenter SPRING registry of the Italian Society of Rheumatology.

Journal of translational autoimmunity·2026
Same author

Safety and effectiveness of tocilizumab in systemic sclerosis: a multicentre French-Italian study.

RMD open·2026
Same author

Risk of intestinal involvement in mucocutaneous-onset Behçet's disease: data from the AIDA network registry.

Frontiers in immunology·2026
Same author

Optimizing Personalized Care Through Multidisciplinary Management in Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Narrative Review.

Journal of personalized medicine·2026
Same author

Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology.

RMD open·2026
Same author

A snapshot of subcutaneous infliximab uses in inflammatory rheumatic diseases: a multicentric Italian study.

Therapeutic advances in musculoskeletal disease·2026

Related Experiment Video

Updated: Jul 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Musculoskeletal involvement in systemic sclerosis.

Silvia Bellando Randone1, Serena Guiducci, Marco Matucci Cerinic

  • 1Department of Biomedicine DENOThe Centre, Division of Rheumatology AOUC, University of Florence, Italy. issis74@libero.it <issis74@libero.it>

Best Practice & Research. Clinical Rheumatology
|May 6, 2008
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) frequently causes musculoskeletal issues like joint pain and muscle weakness, significantly impacting patient quality of life. Early detection and targeted treatments are crucial for managing this disabling aspect of SSc.

Related Experiment Videos

Last Updated: Jul 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Immunology
  • Orthopedics

Background:

  • Systemic sclerosis (SSc) commonly presents with musculoskeletal manifestations.
  • These issues are a primary driver of disability in SSc patients.
  • While visceral involvement dictates prognosis, musculoskeletal complications severely affect quality of life.

Purpose of the Study:

  • To highlight the prevalence and clinical features of musculoskeletal involvement in SSc.
  • To outline diagnostic markers for suspected musculoskeletal SSc.
  • To emphasize the need for improved therapeutic strategies for SSc-related musculoskeletal conditions.

Main Methods:

  • Review of clinical features associated with SSc musculoskeletal involvement.
  • Identification of relevant laboratory markers for diagnosis.
  • Analysis of current treatment gaps and future research directions.

Main Results:

  • Arthralgia is the most common symptom, followed by arthritis, contractures, stiffness, and muscle weakness.
  • Tendon friction rubs indicate a poor prognosis.
  • Recommended laboratory tests include CPK, aldolase, LDH, ALP, RF, and anti-CCP antibodies.

Conclusions:

  • Musculoskeletal involvement is a frequent and disabling complication of SSc.
  • Routine screening and appropriate diagnostic workup are essential.
  • Further research and clinical trials are needed to develop effective treatments for SSc-related musculoskeletal conditions.