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Related Experiment Video

Updated: Jul 5, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
05:32

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Published on: September 21, 2015

Excessive antibiotic use in men with prostatitis.

Brent C Taylor1, Siamak Noorbaloochi, Mary McNaughton-Collins

  • 1Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.

The American Journal of Medicine
|May 6, 2008
PubMed
Summary
This summary is machine-generated.

Antibiotics are frequently prescribed for chronic pelvic pain syndrome (CPPS), despite evidence against their effectiveness. This study highlights significant overuse, particularly of fluoroquinolones, indicating a need for improved prescribing strategies in prostatitis management.

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Area of Science:

  • Urology
  • Infectious Diseases
  • Pharmacology

Background:

  • Prostatitis leads to 2 million annual outpatient visits.
  • Most prostatitis cases are chronic pelvic pain syndrome (CPPS), not requiring routine antibiotics.
  • CPPS diagnosis and management present significant challenges in urological care.

Purpose of the Study:

  • To quantify antibiotic use in men diagnosed with chronic pelvic pain syndrome (CPPS).
  • To compare antibiotic prescribing patterns for CPPS versus other prostatitis diagnoses.
  • To identify the extent of unnecessary antibiotic prescriptions in CPPS.

Main Methods:

  • Utilized Veterans Health Administration inpatient, outpatient, and pharmacy datasets.
  • Defined CPPS by excluding infectious/acute prostatitis and urinary tract infections.
  • Analyzed antibiotic prescription data, focusing on fluoroquinolones.

Main Results:

  • CPPS affects 0.5% of men annually.
  • 49% of men with CPPS received fluoroquinolone prescriptions, versus 5% without CPPS.
  • Men with CPPS were over 7 times more likely to receive fluoroquinolones, independent of other factors.

Conclusions:

  • Antibiotics were prescribed to 69% of men with CPPS, despite limited efficacy.
  • While confounding factors exist, a 7-fold increase in fluoroquinolone use is notable.
  • Strategies to reduce unnecessary antibiotic prescribing for prostatitis are urgently needed.