mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells
Arti Parihar1, Mordhwaj S Parihar, Zhonghai Chen
1Department of Surgery, Heart and Lung Research Institute, and Institute of Mitochondrial Biology, The Ohio State University, Columbus, Ohio, USA.
Abstract:
mAtNOS1 is a novel gene recently reported in mammalian genome with functions that are not fully understood. The present study shows that in human mammary adenocarcinoma MCF-7 cells, mAtNOS1 expression increases mitochondrial nitric oxide and calcium. Our study further shows that overexpression of mAtNOS1 induces apoptosis in MCF-7 cells by increasing mitochondrial protein tyrosine nitration and cytochrome c release. The present study suggests a novel function for mAtNOS1 in regulating mitochondrial nitric oxide and calcium and inducing apoptosis of MCF-7 cells.
