Related Experiment Video
Updated: Jul 5, 2026

Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
Published on: March 24, 2023
Pilot study: understanding the effects of voicing intervention on HFCC therapy in people with cystic fibrosis
Wha Jung Yoo1, Jane Braverman, Yong Wan Lee
1Program in Rehabilitation Science, University of Minnesota, Minneapolis, Minnesota.
Abstract:
The efficacy of High-Frequency Chest Compression (HFCC) airway clearance therapy is linked to the induced-peak expiratory airflow pulse (IPEF) at the patient's mouth. The authors' goal was to determine the conditions that yield the highest IPEF using HFCC running at 6Hz in conjunction with voicing intervention. A pilot experimental study was conducted in a laboratory setting. Six adults with moderate to mild cystic fibrosis (CF) and 10 healthy adults participated. When the component characteristics of voicing were disregarded in data analysis of four conditions, voicing only intervention (V(1)I(0)), HFCC only intervention (V(0)I(1)), voicing intervention and HFCC intervention combinations (V(1)I(1)) and nonintervention (V(0)I(0)), V(0)I(1) had significantly higher (P<0.0001) IPEF. Data analyses of 64 separate voicing component characteristics, frequency (x4), amplitude (x4), and rhythm (x2) of voicing intervention, in addition to absence and presence of HFCC intervention (V(1)I(0) and V(1)I(1)), were examined. One condition in V(1)I(0) had significantly higher (P<0.000001) IPEF than other conditions in V(1)I(0) and V(1)I(1) in both experimental and control groups. Based on these findings, V(1)I(1) may yield higher IPEF than V(0)I(1). One condition of amplitude component of voicing and one condition of rhythm component of voicing had significantly higher (P<0.0001) IPEF than other conditions of amplitude and rhythm components in both CF and control subjects. Analysis of this combined condition of V(1)I(1) showed that this specific condition of V(1)I(1) had significantly higher (P<0.000001) IPEF than any other conditions in V(1)I(1) and V(0)I(1).
Related Concept Videos
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Pulmonary Function Tests
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Chest Physiotherapy
Purpose
CPT is primarily used for patients with excessive bronchial secretions who have difficulty clearing...
