Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Physiology of the Gastrointestinal System II: Digestion and Absorption01:22

Physiology of the Gastrointestinal System II: Digestion and Absorption

The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
Histology of the Small Intestine01:27

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Purine salvage pathway protects CD8<sup>+</sup> T cells from metabolic stress.

Nature immunology·2026
Same author

Activation-induced cytidine deaminase: The missing piece of many puzzles.

Cell·2025
Same author

mTORC1-independent IgA production: a unique pathway for gut immune homeostasis.

International immunology·2025
Same author

Monitoring ferroptosis in vivo: Iron-driven volatile oxidized lipids as breath biomarkers.

Redox biology·2025
Same author

Prediction of postoperative delirium by blood metabolome analysis.

Journal of psychiatric research·2025
Same author

Metabolism and metabolites regulating hematopoiesis.

Current opinion in immunology·2025

Related Experiment Video

Updated: Jul 5, 2026

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
11:34

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

Evolution, development, mechanism and function of IgA in the gut.

Sidonia Fagarasan1

  • 1Laboratory for Mucosal Immunity, RIKEN Research Center for Allergy and Immunology, 230-0045 Tsurumi, Yokohama, Japan. sidonia-f@rcai.riken.jp

Current Opinion in Immunology
|May 6, 2008
PubMed
Summary

Immunoglobulin A (IgA) is key for mucosal immunity. Recent research reveals new locations, mechanisms, and functions for IgA synthesis, enhancing our understanding of its protective roles at body surfaces.

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

Related Experiment Videos

Last Updated: Jul 5, 2026

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
11:34

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • Immunoglobulin A (IgA) is the most abundant antibody at mucosal surfaces.
  • Established knowledge indicates IgA plasma cell precursors are generated in gut-associated lymphoid tissues with CD4 T cell help.
  • Secretory IgA (sIgA) is known to protect against mucosal pathogens.

Purpose of the Study:

  • To explore recent conceptual advances in mucosal IgA synthesis.
  • To identify novel sites, mechanisms, and functions of IgA production.
  • To deepen the understanding of IgA's role in mucosal immunity.

Main Methods:

  • Review of recent immunological and microbiological research.
  • Analysis of studies investigating IgA plasma cell generation.
  • Examination of functional studies on secretory IgA.

Main Results:

  • Identification of previously unrecognized sites of IgA synthesis.
  • Elucidation of novel regulatory mechanisms governing IgA production.
  • Discovery of new functions for IgA in mucosal defense and homeostasis.

Conclusions:

  • Mucosal IgA synthesis is more complex and widespread than previously thought.
  • Emerging research expands the known roles of IgA in maintaining mucosal health.
  • Further investigation into IgA's diverse functions is warranted for therapeutic applications.