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Case presentation: nephrolithiasis in a patient treated with atazanavir
Carolyn Savini1, Christopher James, Susan Wilson
1HIV Program at Christiana Care Health System in Delaware, USA.
Summary
Atazanavir is a popular HIV medication, but recent reports indicate a risk of kidney stones (nephrolithiasis). This case study highlights a patient who developed nephrolithiasis while on atazanavir-containing antiretroviral therapy.
Area of Science:
- Infectious Diseases
- Pharmacology
- Nephrology
Background:
- Atazanavir is a widely used protease inhibitor for HIV treatment, favored for its efficacy and convenient dosing.
- Advantages include a good side effect profile, minimal lipid impact, and a low pill burden.
- Emerging data suggests potential adverse events with newer antiretroviral drugs.
Observation:
- This report details a case of nephrolithiasis (kidney stones).
- The patient was undergoing combination antiretroviral therapy.
- The regimen included the antiretroviral medication atazanavir.
Findings:
- Nephrolithiasis occurred in a patient receiving atazanavir-based antiretroviral therapy.
- This aligns with recent reports linking atazanavir to kidney stone formation.
- Further investigation into this specific side effect is warranted.
Implications:
- Clinicians should be aware of the potential for atazanavir-associated nephrolithiasis.
- Monitoring for kidney stone development may be necessary in patients on atazanavir.
- This finding contributes to the understanding of long-term antiretroviral therapy side effects.
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