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Updated: Jul 5, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

An electrospun triphasic nanofibrous scaffold for bone tissue engineering.

S A Catledge¹, W C Clem, N Shrikishen

¹Department of Physics, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA. catledge@uab.edu

Biomedical Materials (Bristol, England)

|May 7, 2008

Summary

This study developed a novel triphasic scaffold using polycaprolactone, collagen, and hydroxyapatite nanoparticles for bone tissue engineering. The scaffold demonstrated promising mechanical properties and uniform particle dispersion, crucial for osteoconductive applications.

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Published on: June 18, 2014

Area of Science:

Biomaterials Science
Tissue Engineering
Nanotechnology

Background:

Bone tissue engineering requires scaffolds mimicking the native extracellular matrix.
Developing osteoconductive materials with appropriate mechanical properties is essential for bone regeneration.

Purpose of the Study:

To fabricate and characterize a novel nanofibrous triphasic scaffold composed of polycaprolactone (PCL), type-I collagen, and hydroxyapatite nanoparticles (nano-HA).
To evaluate the scaffold's fiber morphology, chemical composition, nanoparticle dispersion, and mechanical properties.

Main Methods:

Electrospinning of a PCL/collagen/nano-HA mixture (50/30/20 ratio).
Characterization using Scanning Electron Microscopy (SEM), Confocal Microscopy, Transmission Electron Microscopy (TEM), and nanoindentation.
Evaluation of different scaffold compositions including pure PCL, pure collagen, and binary mixtures.

Main Results:

SEM revealed nanofibrous morphology with an average diameter of 180 ± 50 nm, similar to native collagen fibers.
Confocal and TEM microscopy confirmed uniform dispersion of nano-HA particles (average size 30 nm) with minor agglomeration.
Nanoindentation showed a Young's modulus ranging from 0.50-3.9 GPa, with the triphasic scaffold exhibiting favorable mechanical properties.

Conclusions:

The developed triphasic scaffold shows potential as an osteoconductive material for bone regeneration.
Collagen plays a critical role in influencing the mechanical properties of these composite scaffolds.
The findings highlight the importance of material composition and nanoparticle integration for scaffold performance.