Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neutral proteases in regenerating bone.

T A Einhorn1, R J Majeska

  • 1Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029-6574.

Clinical Orthopaedics and Related Research
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recommendations for the conduct of economic evaluations in osteoporosis: outcomes of an experts' consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the US branch of the International Osteoporosis Foundation.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Osteoarthritis and stem cell therapy in humans: a systematic review.

Osteoarthritis and cartilage·2018
Same author

Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes.

Osteoarthritis and cartilage·2015
Same author

Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation.

Journal of the mechanical behavior of biomedical materials·2013
Same author

High resolution micro arthrography of hard and soft tissues in a murine model.

Osteoarthritis and cartilage·2012
Same author

Activation of bone remodeling after fatigue: differential response to linear microcracks and diffuse damage.

Bone·2010
Same journal

Impact Microindentation Evaluates Bone Strength, Bone Quality, and Fracture Susceptibility Across Skeletal Sites: A Cadaver Study.

Clinical orthopaedics and related research·2026
Same journal

What Is the Effect of Robot Reduction in Displaced Pelvic Fractures? A Multicenter Randomized Clinical Trial.

Clinical orthopaedics and related research·2026
Same journal

CORR Insights®: Acute or Delayed TKA for Tibial Plateau Fracture? An Observational Study From the Swedish Arthroplasty Register.

Clinical orthopaedics and related research·2026
Same journal

Reply to the Letter to the Editor: Guest Editorial: Recalling a Recall.

Clinical orthopaedics and related research·2026
Same journal

Radial Head Fractures Cluster in the Anterolateral and Anteromedial Quadrants and Do Not Correlate With Coronoid Fracture Types.

Clinical orthopaedics and related research·2026
Same journal

Reduced Cerebellar Activation With Eyes Closed Is Associated With Delayed Peroneal Reaction Time in Patients With Chronic Ankle Instability.

Clinical orthopaedics and related research·2026
See all related articles

Neutral proteases play a key role in bone formation and remodeling by modifying extracellular matrix proteins. These enzymes, active at physiologic pH, are crucial for processes like fracture healing and bone maintenance.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Orthopedics

Background:

  • Neutral proteases, active at physiologic pH, are integral to bone formation, modeling, and remodeling.
  • These enzymes modify extracellular matrix proteins and proteoglycans, facilitating calcification in various ossification systems.

Purpose of the Study:

  • To elucidate the multifaceted roles of neutral proteases in bone biology.
  • To understand the mechanisms of neutral protease involvement in both normal and malignant osteogenesis.
  • To explore the regulation of neutral proteases by calciotropic hormones.

Main Methods:

  • The study is primarily a review and synthesis of existing research on neutral proteases in bone.
  • Analysis of enzyme characteristics (molecular weight, charge, ion dependence) and cellular origins.

Related Experiment Videos

  • Examination of the interplay between neutral proteases, osteoblasts, osteoclasts, and calciotropic hormones.

    • Main Results:

    • Neutral proteases modify extracellular matrix for calcification during endochondral ossification, fracture healing, and osteophyte formation.
    • In malignant osteogenesis (osteosarcoma), osteoblasts produce neutral proteases acting on osteoid.
    • Osteoblasts secrete inactive collagenase and activators/inhibitors, crucial for osteoid removal and bone remodeling, regulated by calciotropic hormones.

    Conclusions:

    • Neutral proteases are essential for bone matrix modification and calcification across diverse physiological and pathological contexts.
    • Osteoblast-derived neutral proteases, regulated by hormones, are critical for bone remodeling and osteoid maintenance.
    • Further research into neutral protease functions may reveal therapeutic targets for bone diseases.