Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Congenital perineal and perianal lipoma with and without anorectal malformation. A case series of eleven patients and updated literature review.

Journal of pediatric surgery·2026

Same author

Predicting fusion ignition at the National Ignition Facility with physics-informed deep learning.

Science (New York, N.Y.)·2025

Same author

Patient-reported outcomes and comprehensive assessment of wrist function after scaphoid reconstruction: A single-center retrospective study on 162 patients.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2024

Same author

[Esthetic reconstruction of traumatic defects by plastic surgery].

Unfallchirurgie (Heidelberg, Germany)·2024

Same author

Quality of Life After Severe Burn Injury: A Case Report.

Annals of burns and fire disasters·2024

Same author

The impact of low-mode symmetry on inertial fusion energy output in the burning plasma state.

Nature communications·2024

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Protocol to Create Chronic Wounds in Diabetic Mice

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

[Future treatment options for chronic wounds].

L Steinsträsser¹, R Hasler, T Hirsch

¹Klinik für Plastische Chirurgie und Schwerbrandverletzte, BG-Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland. lars.steinstraesser@ruhr-uni-bochum.de

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen

|May 7, 2008

Summary

This summary is machine-generated.

Chronic wounds compromise the skin barrier, impacting patient quality of life and causing economic burdens. Novel treatments can accelerate healing, reduce healthcare costs, and improve patient outcomes.

Related Experiment Videos

Last Updated: Jul 5, 2026

Protocol to Create Chronic Wounds in Diabetic Mice

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Area of Science:

Dermatology
Immunology
Regenerative Medicine

Context:

The skin acts as a crucial immune barrier against pathogens.
Chronic wounds breach this barrier, leading to impaired immunity and patient distress.
These wounds significantly reduce quality of life and can cause social and economic hardship.

Purpose:

To review current and future therapeutic strategies for chronic wound management.
To highlight the importance of evidence-based treatments in accelerating healing.
To discuss approaches in wound conditioning, therapy, and regeneration.

Summary:

Chronic wounds impair the skin's immune barrier function, affecting patient well-being and finances.
Effective wound management is essential to restore barrier integrity and patient function.
Novel treatments offer promise for faster healing and reduced healthcare expenditures.

Impact:

Accelerated wound healing reduces treatment duration and associated costs.
Improved wound care enhances patient quality of life and social integration.
Advancements in wound conditioning, therapy, and regeneration are vital for effective management.