[Concentration of cytoplasmic RNA in the endometrium in trophoblastic disease]

The method of cytospectrophotometry was used to determine quantitatively the content of cytoplasmatic RNA in cells of endometrial glands in 28 females who suffered trophoblastic disease. It was found that during the first year after the disease the RNA content in the endometrium in patients, subjected to chemotherapy, was nearly twice as low as in females not treated with methotrexate. Within the same period the RNA content was mostly low in those, who suffered malignant forms of the disease and were injected larger doses of the substance, accordingly. If the duration of the disease was longer than a year, the RNA content in the endometrium in both methotrexate treated and not females proved to be nearly the same, in the former the content being reliably higher than the analogous value in the control group (10 females in a phase of normal menstrual cycle secretion not suffering hydatid mole). During the investigation a correlation was found between changes in the endometrial RNA content and the level of sex hromones excretion.