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Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...

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Related Experiment Video

Updated: Jul 5, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2.

Jeremy A Cholfin1, John L R Rubenstein

  • 1Medical Scientist Training Program, University of California, San Francisco, San Francisco, California 94143-2611, USA.

The Journal of Comparative Neurology
|May 7, 2008
PubMed
Summary

Fibroblast growth factors (Fgf8, Fgf17) and Emx2 are crucial for frontal cortex development. They regulate gene expression, influencing the formation of distinct frontal cortex subdivisions in newborn mice.

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Last Updated: Jul 5, 2026

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13:47

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Published on: April 3, 2013

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • The frontal cortex (FC) is vital for cognition, movement, and behavior.
  • Genetic mechanisms governing FC development are largely unknown.
  • Previous work identified gene expression markers for neonatal FC subdivisions and FC regionalization defects in Fgf17 mutant mice.

Purpose of the Study:

  • To investigate the roles of Fgf8, Fgf17, and Emx2 in the molecular regionalization of frontal cortex subdivisions.
  • To examine regionalization phenotypes in Fgf8(neo/neo), Emx2-/-, and Emx2-/-;Fgf17-/- newborn mice.
  • To propose a model for fibroblast growth factor regulation of FC patterning.

Main Methods:

  • Application of a frontal cortex gene expression marker panel to mutant mice.
  • Analysis of regionalization phenotypes in Fgf8(neo/neo), Emx2-/-, and Emx2-/-;Fgf17-/- newborn mice.
  • Examination of gene expression changes in the rostral cortical neuroepithelium.

Main Results:

  • Fgf8, Fgf17, and Emx2 exhibit distinct roles in frontal cortex molecular regionalization.
  • Altered expression of Spry1, Spry2, Er81, Erm, Pea3, and Sp8 indicates differential effects of Fgf8 and Fgf17 signaling.
  • Emx2 and Fgf17 antagonistically regulate Erm, Pea3, and Er81 expression, impacting FC regionalization.

Conclusions:

  • Fibroblast growth factors and Emx2 play critical, distinct roles in frontal cortex regionalization.
  • These factors regulate regional transcription factor expression within the frontal cortex anlage.
  • A model is proposed for how fibroblast growth factors orchestrate frontal cortex patterning.