Related Experiment Video
Updated: Jul 5, 2026
Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography
Published on: January 7, 2015
Evaluation of injectable CaHA for the treatment of mid-face volume loss
Kenneth Beer1, Monica Yohn, Joel L Cohen
1Palm Beach Esthetic Center, West Palm Beach, FL 33401, USA. kenbeer@aol.com
Background:
Calcium hydroxylapatite (CaHA) is presently approved for the correction of moderate to severe facial wrinkles and folds and signs of HIV-associated facial lipoatrophy.
Objective:
This 6-month pilot study was designed to evaluate clinical efficacy and patient satisfaction of CaHA to treat mid-face volume loss.
Methods:
Nineteen patients received initial malar injections of CaHA. At 1, 3, and 6 months, patients were evaluated for mid-face volume loss, satisfaction, and adverse events. Touch ups were administered at 3 months, with enhancement injections permitted at 6 months.
Results:
Average treatment volumes were 1.3 mL CaHA gel per side. At 1, 3, and 6 months, 88%, 74%, and 75% of patients rated themselves "very satisfied/satisfied" and physicians rated 82%, 100%, and 94% of patients as "im proved" or greater, respectively. Global Aesthetic Improvement Scale (GAIS) scores were similar. At 6 months, 88% of patients were pleased with the outcome and 81% would recommend CaHA cheek augmentation.
Conclusions:
Malar augmentation with CaHA gel appears to be a viable nonsurgical alternative for patients with mid-face volume loss, with good patient satisfaction and excellent tolerability.