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Correlation of modified Gleason grading with pT stage of prostatic carcinoma after radical prostatectomy
1Department of Pathology, General Hospital HBH Kliniken Singen, Academic Hospital of the University of Freiburg, Singen, Germany.
Objective:
To study the correlation between modified Gleason score (GS) and pT stage of radical prostatectomy (RP) specimens.
Study Design:
Six hundred forty-nine consecutive RP specimens were graded according to the conventional and the modified Gleason grading systems.
Results:
A total of 29% of the tumors were upgraded. Both variants of GS correlated with pathologic stage. Stage pT2 tumors were assigned a GS of 3-6 less often with modified grading than with conventional grading (29% and 84%, respectively). The only significant difference of stage distribution between conventional and modified GS was for GS 7, where pT2 was the most common stage with modified grading (54%) and pT3 was most common with conventional grading (67%). Of GS 3 + 4 = 7a tumors, 95% were stage pT2, while 79% of GS 4 + 3 = 7b tumors were stage pT3-4.
Conclusion:
The stage distribution of modified GSs of RP specimens differs from that of conventional GSs, but a good correlation exists between grade and pT stage. Notably, GS 4 + 3 = 7b was more often associated with high stage than was GS 3 + 4 = 7a.
