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Related Experiment Videos

3 alpha-Androstanediol glucuronide in premature and normal pubarche.

L M Riddick1, L R Garibaldi, M E Wang

  • 1Department of Pediatrics, University of Illinois College of Medicine, Chicago 60612.

The Journal of Clinical Endocrinology and Metabolism
|January 1, 1991
PubMed
Summary

Adrenal androgens dehydroepiandrosterone sulfate (DS), dehydroepiandrosterone (DHEA), and androstenedione (delta 4-A) significantly contribute to 3 alpha-androstanediol glucuronide (3AG) production in children. This is observed in both premature and normal pubarche, highlighting the role of weaker adrenal androgens.

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Area of Science:

  • Pediatric Endocrinology
  • Reproductive Endocrinology
  • Steroid Biochemistry

Background:

  • Adrenal androgens play a crucial role in pubertal development.
  • Understanding the precursors of 3 alpha-androstanediol glucuronide (3AG) is essential for diagnosing adrenal disorders.
  • Premature pubarche can result from various conditions, including idiopathic premature adrenarche and specific enzyme deficiencies.

Purpose of the Study:

  • To investigate the contribution of adrenal androgens to 3 alpha-androstanediol glucuronide (3AG) production in children.
  • To compare 3AG and androgen levels in children with premature pubarche versus normal prepubertal and pubertal children.

Main Methods:

  • Serum levels of 3AG, dehydroepiandrosterone (DHEA), DHEA sulfate (DS), androstenedione (delta 4-A), and testosterone (T) were measured.

Related Experiment Videos

  • Measurements were performed in 32 children with premature pubarche (idiopathic premature adrenarche, 21-hydroxylase deficiency, 3 beta-hydroxysteroid dehydrogenase deficiency) and compared to 36 normal prepubertal and 22 normal pubertal children.

    • Main Results:

    • Children with idiopathic premature adrenarche exhibited significantly higher serum 3AG and androgen levels (except testosterone) compared to normal prepubertal children.
    • Serum 3AG and androgen levels (except testosterone) were elevated in children with 21-hydroxylase or 3 beta-hydroxysteroid dehydrogenase deficiency compared to prepubertal controls.
    • 3AG levels correlated more strongly with DS, DHEA, and delta 4-A than with testosterone, suggesting these weaker androgens are key precursors.

    Conclusions:

    • Weak adrenal androgens, specifically DS, DHEA, and delta 4-A, substantially contribute to 3AG production in both premature and normal pubarche.
    • These findings underscore the importance of assessing adrenal androgen status in the evaluation of childhood pubertal development and related disorders.