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Updated: Jul 5, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Dubin-Johnson syndrome.

Aziz-un Nisa¹, Zubair Ahmad

¹Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|May 8, 2008

Summary

Dubin-Johnson syndrome is a benign genetic disorder causing recurrent jaundice due to impaired bilirubin transport. This condition, characterized by dark liver pigment, requires no treatment and has a normal life expectancy.

Area of Science:

Hepatology
Medical Genetics

Background:

Dubin-Johnson syndrome is an inherited disorder affecting bilirubin metabolism.
It is characterized by recurrent episodes of conjugated hyperbilirubinemia and mild jaundice.

Observation:

A young male patient presented with recurrent mild jaundice.
Liver function tests were normal except for elevated conjugated bilirubin.
Liver biopsy revealed characteristic dark brown pigment deposition in hepatocytes.

Findings:

The syndrome results from a defect in the canalicular protein MRP2 (multidrug resistance-associated protein 2).
This defect impairs the biliary secretion of conjugated bilirubin and other organic anions.
Genetic analysis identified the MRP2 defect on chromosome 10q24.

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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Implications:

Dubin-Johnson syndrome is a benign condition with no long-term health consequences.
Patients typically have a normal life expectancy and do not require specific medical treatment.
Accurate diagnosis through liver biopsy and genetic testing is crucial for patient management.