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Related Concept Videos

Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

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Related Experiment Video

Updated: Jul 5, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Swyer-James-MacLeod Syndrome.

Kanwal Fatima Khalil1, Waseem Saeed

  • 1Department of Pulmonology, Military Hospital, Rawalpindi. kfbaloch@hotmail.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|May 8, 2008
PubMed
Summary

Swyer-James-MacLeod Syndrome (SJMS) is a rare acquired lung disease. Diagnosis in an adult male was confirmed using chest X-ray, HRCT, and lung scans, indicating childhood pneumonia as a cause.

Area of Science:

  • Pulmonology
  • Radiology
  • Nuclear Medicine

Background:

  • Swyer-James-MacLeod Syndrome (SJMS) is a rare, acquired pulmonary condition.
  • It is typically associated with severe childhood pneumonia leading to post-infectious bronchiolitis obliterans.

Observation:

  • This case report details an adult male diagnosed with SJMS.
  • Diagnostic modalities included standard chest X-ray, high-resolution computed tomography (HRCT) of the chest, and radionuclide perfusion lung scintigraphy.

Findings:

  • Imaging findings confirmed the diagnosis of SJMS.
  • The patient's history suggested a link between early childhood pneumonias and the development of this rare syndrome.

Implications:

  • This case highlights the importance of recognizing SJMS in adults presenting with relevant respiratory symptoms.

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Last Updated: Jul 5, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

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Published on: May 1, 2015

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

  • Diagnostic imaging plays a crucial role in identifying characteristic lung abnormalities associated with SJMS.
  • Understanding the etiology, often linked to childhood infections, is key for potential early intervention or monitoring.