Related Experiment Video

Updated: Jul 5, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology

Reema H Syed1, Brooke E Gilliam, Terry L Moore

  • 1Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Room 211A Doisy Hall, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA.

Current Rheumatology Reports
|May 8, 2008
PubMed

Insights

Juvenile idiopathic arthritis (JIA) lacks biomarkers. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody isotypes show promise in assessing JIA severity and guiding treatment to prevent joint damage.

Area of Science:

  • Pediatrics
  • Immunology
  • Rheumatology

Background:

  • Juvenile idiopathic arthritis (JIA) is a complex childhood disease.
  • Reliable biomarkers for monitoring JIA progression are currently lacking.
  • Immunoglobulin (Ig) M rheumatoid factor (RF) defines a JIA subset, but its measurement method impacts significance.

Purpose of the Study:

  • To evaluate the role of RF isotypes and anti-cyclic citrullinated peptide (anti-CCP) antibody isotypes in JIA.
  • To determine the utility of these antibodies in assessing disease severity and outcome.
  • To explore their potential in guiding treatment strategies for JIA patients.

Main Methods:

  • The study likely involved analyzing RF and anti-CCP antibody levels in JIA patients.
  • Different isotypes of RF and anti-CCP antibodies were assessed.
  • Correlation with disease severity, functional disability, and joint damage was investigated.

Main Results:

  • IgA RF is implicated in JIA disease severity, functional disability, and joint damage.
  • Anti-CCP antibodies have shown varied significance in JIA, with recent studies highlighting isotype usefulness.
  • RF isotypes and anti-CCP isotypic antibodies are increasingly important for JIA evaluation.

Conclusions:

  • RF isotypes and anti-CCP isotypic antibodies are valuable tools for evaluating JIA patients.
  • These markers can help identify patients with more aggressive or severe disease.
  • Their assessment can aid in developing targeted treatment plans to prevent joint damage and disability.

More Related Videos

Anti-Nuclear Antibody Screening Using HEp-2 Cells13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...