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Plasma resistin levels and risk of myocardial infarction and ischemic stroke

Cornelia Weikert1, Sabine Westphal, Klaus Berger

  • 1Department of Epidemiology, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany. weikert@dife.de

The Journal of Clinical Endocrinology and Metabolism
|May 8, 2008
PubMed

Insights

High plasma resistin levels predict increased risk of myocardial infarction (MI), but not ischemic stroke (IS). This study highlights resistin

Area of Science:

  • Endocrinology
  • Cardiovascular Disease Research
  • Biomarker Discovery

Background:

  • Resistin, a hormone, is implicated in insulin resistance and cardiovascular disease.
  • Previous studies suggest links between resistin and coronary heart disease.
  • Prospective data on resistin and future cardiovascular disease risk are limited.

Purpose of the Study:

  • To examine the association between plasma resistin levels and the risk of myocardial infarction (MI).
  • To investigate the association between plasma resistin levels and the risk of ischemic stroke (IS).
  • To provide prospective data on resistin's role in cardiovascular disease development.

Main Methods:

  • A case-cohort study design was employed within the European Investigation into Cancer and Nutrition-Potsdam Study.
  • Baseline plasma resistin levels were measured in 26,490 middle-aged participants.
  • Follow-up averaged 6 years, identifying incident MI, IS, or cardiovascular event-free individuals.

Main Results:

  • Individuals in the highest quartile of plasma resistin showed a significantly increased risk of MI (RR 2.09).
  • This association remained significant after adjusting for cardiovascular risk factors, including C-reactive protein.
  • No significant association was found between plasma resistin levels and the risk of IS (RR 0.94).

Conclusions:

  • Elevated plasma resistin levels are associated with a higher risk of myocardial infarction.
  • Plasma resistin levels do not appear to be significantly associated with the risk of ischemic stroke.
  • Further research is warranted to confirm the predictive value of resistin for cardiovascular events.
Abstract

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