Approach to percutaneous closure in patients with multiple atrial septal defects

In most patients with an atrial septal defect or patent foramen ovale, a single defect of the interatrial septum may be closed with a single device. However, patients with multiple defects of the interatrial septum may require the use of multiple devices, which involves some technical challenges. We present 5 cases requiring 2 closure devices with clinical and echocardiographic follow up ranging from 3 months to 4 years, demonstrating a high success and low complication rates.