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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Healing II: Complications

Healing II: Complications

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Rheumatic Heart Disease I: Introduction

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Cardiomyopathy IV: Restrictive Cardiomyopathy

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Atherosclerosis I: Introduction

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Cirrhosis I: Introduction

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Updated: Jul 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Scleroderma.

Anita C Gilliam¹

¹Department of Dermatology, Case/University Hospitals of Cleveland, Cleveland, Ohio, USA. gilliaa@pamf.org

Current Directions in Autoimmunity

|May 8, 2008

Summary

This summary is machine-generated.

Scleroderma, a complex autoimmune disease, involves genetic predisposition and immune, vascular, and matrix abnormalities, leading to excess collagen. Early stem cell transplantation may offer the most effective treatment for systemic sclerosis.

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Last Updated: Jul 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Immunology
Dermatology
Rheumatology

Background:

Scleroderma is a distinct autoimmune disease characterized by excess collagen deposition, unlike other skin autoimmune conditions that cause epithelial injury.
Its pathogenesis is multifactorial, involving genetic predisposition, immune dysregulation, vascular abnormalities, and extracellular matrix issues.

Purpose of the Study:

To explore the diverse hypotheses regarding the pathophysiology of scleroderma (systemic sclerosis).
To discuss current treatment limitations and potential future therapeutic strategies.

Main Methods:

Review of existing hypotheses on scleroderma pathophysiology.
Discussion of potential therapeutic interventions, including stem cell transplantation.

Main Results:

Scleroderma pathogenesis involves complex interactions including cytokine dysregulation, T and B cell dysfunction, endothelial injury, and matrix homeostasis disruption.
Current therapies are largely ineffective, with vascular agents offering limited utility.

Conclusions:

Systemic sclerosis is a chronic, progressive disease with no definitive cure.
Hematopoietic stem cell transplantation prior to significant fibrosis presents a promising therapeutic avenue.