Related Experiment Video

Updated: Jul 5, 2026

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1
12:00

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1

Published on: April 8, 2009

Temporal relationship between human parechovirus 1 infection and otitis media in young children

Sisko Tauriainen1, Sami Oikarinen, Kirsi Taimen

  • 1Dept. of Virology, University of Tampere Medical School, 33014 University of Tampere, Tampere, Finland. Sisko.Tauriainen@uta.fi

The Journal of Infectious Diseases
|May 9, 2008
PubMed

Insights

Human parechovirus (HPeV) 1 infections are common in childhood and frequently cause otitis media. This study also found a link between HPeV1 and cough in children.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Human parechovirus (HPeV) 1 is a ubiquitous childhood virus with poorly documented clinical manifestations.
  • Prospective cohort study to evaluate symptoms associated with HPeV1 infection in children from birth.

Purpose of the Study:

  • To determine the clinical symptoms associated with Human parechovirus (HPeV) 1 infection in a pediatric cohort.
  • To investigate the link between HPeV1 and common childhood illnesses like otitis media and cough.

Main Methods:

  • Prospective follow-up of 59 children from birth at 3-month intervals.
  • Symptom data collected via hospital records and parental questionnaires.
  • HPeV1 infection diagnosed by neutralizing antibodies; HPeV RNA analyzed in middle ear fluid and nasopharyngeal samples using RT-PCR.

Main Results:

  • Otitis media showed a strong association with HPeV1 infection (OR, 6.14).
  • HPeV1 RNA detected in 15% of middle ear fluid samples from children with recurrent otitis media.
  • Cough was also associated with HPeV1 infection, though less strongly (OR, 3.67).

Conclusions:

  • Human parechovirus (HPeV) 1 infections are common in childhood.
  • HPeV1 infection is a significant cause of otitis media and may also contribute to cough in children.
Abstract

More Related Videos

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 210:55

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 2

Published on: April 10, 2009

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...