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An algorithm for applying flagged Sysmex XE-2100 absolute neutrophil counts in clinical practice
Lennart Friis-Hansen1, Lone Saelsen, Steen Z Abildstrøm
1Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark. lfh@rh.dk
European Journal of Haematology
|May 9, 2008
Summary
A new algorithm can identify valid automated absolute neutrophil counts (ANC) from flagged hematology results. This streamlines workflows by reducing manual reviews when only ANC is needed, speeding up patient care.
Area of Science:
- Clinical Pathology
- Hematology Automation
Background:
- Automated differential leukocyte counts often require manual review due to flagged results, increasing turnaround time.
- Frequently, only the absolute neutrophil count (ANC) is clinically relevant.
Purpose of the Study:
- To develop and validate an algorithm for identifying valid automated ANC from flagged Sysmex XE-2100 results.
- To reduce unnecessary manual differential counts in clinical practice.
Main Methods:
- Collected 1448 flagged results from Sysmex XE-2100 for training a validation algorithm.
- Tested the algorithm on an independent set of 1371 flagged results.
Main Results:
- The algorithm identified valid ANCs after excluding results flagged with 'WBC abnormal scattergram'.
- Excellent correlation (r = 0.95-0.99) was observed between automated and manual ANCs post-exclusion.
- Algorithm validity was confirmed on an independent dataset.
Conclusions:
- A simple algorithm can reliably extract valid ANC from flagged automated differential counts.
- This method significantly shortens turnaround time for ANC, enabling faster clinical decision-making.
