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Updated: Jul 5, 2026

On-line Analysis of Nitrogen Containing Compounds in Complex Hydrocarbon Matrixes
Published on: August 5, 2016
Structure analysis of aromatic medicines containing nitrogen using near-infrared spectroscopy and generalized
Hao Liu1, Hongbin Gao, Lingbo Qu
1Department of Pharmacy, Guangdong Food and Drug Vocational College, Guangzhou 510520, Guangdong, China. liu2112003@hotmail.com
Abstract:
Four aromatic medicines (acetaminophen; niacinamide; p-aminophenol; nicotinic acid) containing nitrogen were investigated by FT-NIR (Fourier transform near-infrared) spectroscopy and generalized two-dimensional (2D) correlation spectroscopy. The FT-NIR spectra were measured over a temperature range of 30-130 degrees C. By combining near-infrared spectroscopy, generalized 2D correlation spectroscopy and references, the molecular structures (especially the hydrogen bond related with nitrogen) were analyzed and the NIR band assignments were performed. The results will be helpful to the understanding of aromatic medicines containing nitrogen and the utility of these substances.
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The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse.

