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Updated: Jul 5, 2026

Investigating Outer Hair Cell Motility with a Combination of External Alternating Electrical Field Stimulation and High-speed Image Analysis
Published on: July 18, 2011
Voltage-dependent outer hair cell stereocilia stiffness at acoustic frequencies
1Department of Speech Language and Hearing Sciences, Texas Tech University - Health Sciences Center, Lubbock, Texas 79430, USA. Ming.zhang@ttuhsc.edu
Abstract:
The aim of this report is to show the effects of voltage changes on stereocilia stiffness in mammalian outer hair cells (OHCs). With the OHC cuticular plate anchored at a microchamber tip, step voltage commands drove an OHC inside the microchamber to move freely while stereocilia were oscillated at 510 Hz by a constant fluid-jet force. With basolateral OHC depolarized and shortened, the amplitude of stereocilia motion was increased, suggesting a decrease in stereocilia stiffness. Such a decrease in stiffness may serve as an important adjusting factor inside the cochlear amplifying loop.
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