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Granulocyte function in untreated acute and chronic granulocytic leukemia
Acta Haematologica
|January 1, 1976
Summary
Patients with acute granulocytic leukemia have impaired microbicidal activity, sometimes linked to myeloperoxidase deficiency. Chronic granulocytic leukemia shows normal microbial killing but some neutrophil function disturbance.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Neutrophil dysfunction can increase infection risk in leukemia patients.
- Microbicidal activity and nitro-blue tetrazolium reduction are key neutrophil functions.
Purpose of the Study:
- To investigate neutrophil function in untreated acute and chronic granulocytic leukemia.
- To correlate neutrophil function with infection susceptibility.
Main Methods:
- Assessed microbicidal activity in leukemia patients.
- Evaluated myeloperoxidase (MPO) deficiency.
- Measured nitro-blue tetrazolium (NBT) reduction capacity in neutrophils.
Main Results:
- Untreated acute granulocytic leukemia patients exhibited impaired microbicidal activity.
- One patient with acute granulocytic leukemia had MPO deficiency and staphylococcal infection.
- Chronic granulocytic leukemia patients showed normal microbial killing but reduced NBT reduction, indicating neutrophil dysfunction.
Conclusions:
- Neutrophil dysfunction, particularly impaired microbicidal activity and MPO deficiency, is a concern in acute granulocytic leukemia.
- While microbial killing is preserved in chronic granulocytic leukemia, neutrophil function may still be subtly disturbed.