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Updated: Jul 5, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Monoindole alkaloids from a marine sponge Spongosorites sp
Baoquan Bao1, Ping Zhang, Yoonmi Lee
1College of Pharmacy, Pusan National University, Busan 609-735, Korea. baorchon@yahoo.com
Abstract:
Seven (1-7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1-5 are unique indole pyruvic acid derivatives. Compounds 1-2 and 4-6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
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