Related Experiment Video
Updated: Jul 5, 2026

09:34
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Sequence recognition and self-sorting of a dipeptide by cucurbit[6]uril and cucurbit[7]uril
Mikhail V Rekharsky1, Hatsuo Yamamura, Young Ho Ko
1Entropy Control Project, ICORP, JST, 2-1 Yamada-oka, Suita 565-0871, Japan. mvr@chem.eng.osaka-u.ac.jp
Abstract:
Cucurbit[7]uril forms very strong complex with zwitterionic dipeptide Phe-Gly with affinity exceeding 10(7) M(-1) and effectively recognizes peptide sequence of Phe-Gly over Gly-Phe as well as Tyr-Gly over Gly-Tyr and Trp-Gly over Gly-Trp with relative affinities of 23 000, 18 000 and 2000, respectively.
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