Related Experiment Video
Updated: Jul 5, 2026

Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
Ca(2+)/calmodulin-dependent protein kinases
1Department of Neurobiology and Anatomy, The University of Texas Medical School-Houston, Houston, Texas 77030, USA.
None:
In this article the calcium/calmodulin-dependent protein kinases are reviewed. The primary focus is on the structure and function of this diverse family of enzymes, and the elegant regulation of their activity. Structures are compared in order to highlight the conserved architecture of their catalytic domains with respect to each other as well as protein kinase A, a prototype for kinase structure. In addition to reviewing structure and function in these enzymes, the variety of biological processes for which they play a mediating role are also examined. Finally, how the enzymes become activated in the intracellular setting is considered by exploring the reciprocal interactions that exist between calcium binding to calmodulin when interacting with the CaM-kinases.
Related Concept Videos
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
cAMP-dependent Protein Kinase Pathways
Amplifying Signals via Second Messengers
What are Second Messengers?
What are Second Messengers?
IP3/DAG Signaling Pathway
