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Updated: Jul 5, 2026
03:08
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
A genomic "roadmap" to "better" drugs
Guochun Liao1, Xun Zhang, David J Clark
1Department of Genetics & Genomics, Roche Palo Alto, Palo Alto, California 94304-1397, USA.
Drug Metabolism Reviews
|May 9, 2008
Summary
Genomic methods can identify genetic variants influencing drug response, improving treatment outcomes and reducing drug development failures. Wider application of these technologies enhances drug safety and patient care.
Area of Science:
- Genomics
- Pharmacogenomics
- Drug Development
Background:
- Pharmacogenomic information can improve treatment outcomes and reduce drug attrition.
- A key limitation is the lack of knowledge regarding genetic variants affecting drug metabolism and response.
Purpose of the Study:
- To examine emerging genomic methods for identifying genetic variants.
- To explore how these methods can generate new data on drug metabolism, mechanism of action, and response predictors.
Main Methods:
- Review and examination of emerging genomic technologies.
- Analysis of their potential to identify genetic determinants of drug response.
Main Results:
- Emerging genomic methods can fill the knowledge gap regarding genetic variants.
- These technologies offer potential for new insights into drug metabolism and action.
Conclusions:
- Wider application of emerging genomic technologies can significantly improve drug safety.
- These advancements promise enhanced patient care and more efficient clinical drug development.
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