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Two new furostanol saponins from Tribulus terrestris L

Tun-Hai Xu1, Ya-Juan Xu, Sheng-Xiu Xie

  • 1Department of Traditional Chinese Medicine Chemistry, Beijing University of Chinese Medicine, Beijing, China.

Journal of Asian Natural Products Research
|May 9, 2008
PubMed

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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...