Related Experiment Video
Updated: Jul 5, 2026
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
[Gorlin syndrome (nevoid basal cell carcinoma syndrome)]
B De-Domingo1, F González, P Lorenzo
1Hospital Universitario de Santiago de Compostela, Santiago de Compostela, España. bdedbar@yahoo.es
Archivos De La Sociedad Espanola De Oftalmologia
|May 9, 2008
Summary
Gorlin syndrome, a genetic disorder, causes basal cell carcinomas and other anomalies. Early detection in young patients, especially with eyelid tumors, is crucial for ophthalmologists.
Area of Science:
- Oncology
- Genetics
- Ophthalmology
Background:
- Gorlin syndrome is an autosomal dominant disorder.
- It is associated with basal cell carcinomas, skeletal, and neurological anomalies.
Observation:
- A 77-year-old male with Parkinson's disease and dementia presented with multiple facial basal cell carcinomas and left eye ectropion.
- He developed respiratory distress due to an ameloblastoma in the left nostril, necessitating surgical intervention.
Findings:
- The case highlights the varied clinical manifestations of Gorlin syndrome.
- Basal cell carcinomas, particularly on the eyelids, can be an early indicator.
Implications:
- Ophthalmologists should consider Gorlin syndrome in young patients with multiple eyelid basal cell carcinomas.
- This underscores the importance of interdisciplinary diagnosis for rare genetic syndromes.
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