Analysis of nonlinear relations between expression profiles by the principal curves of oriented-points approach

Mario Huerta1, Juan Cedano, Enrique Querol

  • 1Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Campus UAB, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain. mario@bioinf.uab.es

Related Concept Videos

Curves Defined by Parametric Equations01:21

Curves Defined by Parametric Equations

A baseball hit into the air follows a parabolic trajectory when air resistance is neglected. The motion can be described within a two-dimensional coordinate system, where both the horizontal displacement and vertical height are functions of time. Instead of expressing the trajectory as a single function of position, the motion is modeled using parametric equations: one function for the horizontal position and another for the vertical position as time progresses. Let the horizontal position be...
Orthogonal Trajectories01:26

Orthogonal Trajectories

Orthogonal trajectories describe the geometric relationship between two families of curves that intersect each other at right angles. One illustrative case involves a family of parabolas that open sideways along the x-axis. These curves share a common shape but differ by a scaling parameter, resulting in a set of curves that all pass through the origin and widen at different rates.Determining Orthogonal TrajectoriesTo identify the orthogonal trajectories for these parabolas, the first step...
Curve Equations01:17

Curve Equations

Curves are essential geometric elements characterized by tangent distance, chord length, middle ordinate, and total arc length. These measurements are crucial in understanding a curve's geometric and spatial properties and are defined by the relationship between its radius and its central angle.The tangent distance (T) refers to the straight-line measurement from the intersection point of two tangents to either the start or end of the curve. This distance is influenced by the curve's radius (R)...
Curvature and Its Interpretation01:25

Curvature and Its Interpretation

Curvature describes how rapidly a curve changes direction at a particular point. A curve with a small curvature bends gently, while a curve with a large curvature turns sharply. For a space curve, the position of a moving object can be described by a vector-valued function r(t), where t often represents time. The direction of motion is determined by the tangent vector, and the unit tangent vector is obtained by normalizing the derivative of the position vector.The unit tangent vector gives the...
Curve Sketching and Derivatives01:22

Curve Sketching and Derivatives

Understanding the behavior of a function through its first and second derivatives is essential for analyzing its graph. Derivatives provide insight into where a function increases or decreases, where it attains local maxima or minima, and how its curvature behaves across different intervals.The first derivative of a function reveals the slope of the tangent line at any given point. Points where the derivative is zero or undefined are considered critical, as they often indicate potential extrema...
Three-Dimensional Analysis of Strain01:29

Three-Dimensional Analysis of Strain

Three-dimensional strain analysis is crucial for understanding how materials deform under stress, particularly in elastic, homogeneous materials. This method employs principal stress axes to simplify complex stress states into more understandable forms. Subjected to stress, a small cubic element within a material either expands or contracts along these axes, transforming into a rectangular parallelepiped. This transformation effectively illustrates the material's deformation. The principal...