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Related Experiment Video

Updated: Jul 5, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

[Neural repair].

Masaaki Kitada¹, Mari Dezawa

¹Department of Anatomy and Neurobiology, Kyoto University Postgraduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|May 10, 2008

Summary

Bone marrow stromal cells (MSCs) can be induced into functional Schwann cells and neurons for neural repair. These cells show promise in animal models for peripheral nerve injury, spinal cord injury, and Parkinson's disease.

Area of Science:

Stem cell biology
Neuroscience
Regenerative medicine

Background:

Stem cell biology offers potential for neural repair.
Bone marrow stromal cells (MSCs) are a viable source for cell differentiation.

Purpose of the Study:

To review the differentiation potential of MSCs for neural repair.
To evaluate MSC-derived cells in animal models of neurological disorders.

Main Methods:

Induction of functional Schwann cells and dopaminergic neurons from MSCs.
Grafting of induced cells into animal models of peripheral nerve injury, spinal cord injury, and Parkinson's disease.

Main Results:

MSCs-derived Schwann cells promoted axonal regeneration and remyelination, aiding functional recovery in peripheral and spinal cord injuries.

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Published on: February 23, 2015

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Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

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MSCs-derived dopaminergic neurons integrated into the host striatum and improved behavioral outcomes in Parkinson's disease models.

Demonstrated effectiveness of MSCs for cell-based therapy in neuro-traumatic and neuro-degenerative conditions.

Conclusions:

MSCs possess significant differentiation potential for neural repair applications.
Cell-based therapy using induced MSCs shows promise for treating neurological injuries and diseases.
Further discussion on the benefits and drawbacks of MSC induction systems is warranted for clinical translation.