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Related Experiment Video

Updated: Feb 9, 2026

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
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Insulin--a growth hormone.

Zvi Laron1

  • 1Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center of Israel, WHO Collaborating Center for the Study of Diabetes in Youth, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel. laronz@clalit.org.il

Archives of Physiology and Biochemistry
|May 10, 2008
PubMed
Summary

Insulin significantly promotes growth in children and animal models. This review clarifies insulin

Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Growth Biology

Background:

  • Insulin shares homology with insulin-like growth factor I (IGF-I).
  • Insulin's actions are interconnected with growth hormone (GH) and IGF-I.
  • Understanding insulin's role in growth is crucial for pediatric health.

Purpose of the Study:

  • To review and synthesize the growth-promoting effects of insulin.
  • To explore the mechanisms underlying insulin-mediated growth.
  • To evaluate clinical and experimental evidence for insulin's impact on growth.

Main Methods:

  • Review of experimental studies using organ cultures of neonatal mouse cartilage.
  • Analysis of studies involving insulin injections in hypophysectomized rats.

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  • Examination of clinical data from infants and children with varying insulin levels.

    • Main Results:

    • Insulin stimulates cartilage cell differentiation and maturation in vitro.
    • Insulin injection promoted tibial growth in hypophysectomized rats.
    • Clinical observations link hypoinsulinemia to short stature and hyperinsulinism to tall stature.

    Conclusions:

    • Insulin demonstrably promotes growth through both experimental and clinical evidence.
    • Further research is needed to elucidate the specific receptor pathways (insulin, IGF-I, or hybrid receptors) mediating insulin's growth effects.
    • Optimizing insulin levels is critical for growth in children with diabetes and related conditions.