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Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity
Y Hoshino1, I Horikawa, M Oshimura
1Department of Hygiene and Oncology, Tokyo Medical and Dental University School of Medicine, Japan.
Biochemical and Biophysical Research Communications
|January 15, 1991
Abstract:
The suppressive activity of normal human chromosome 5 was detected by means of the chromosomal transfer technique using DT cells as recipients. A hybrid clone, which exhibited reduced tumorigenicity, contained chromosomal regions such as 5pter-p15, q21 and q33-qter. Since a familial adenomatous polyposis gene has been reported to be located at 5q21-q22, the suppressive activity of chromosome 5 might be due to this gene.