Related Experiment Video
Updated: Jul 5, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
Published on: June 23, 2022
Involvement of 5-HT receptors in learning and memory
1Laboratoire de Neurobiologie des Comportements, UMR 6562 CNRS, Université de Provence, IBHOP, Traverse Charles Susini, 13388 Marseille Cedex 13, France. froman@newsup.univ-mrs.fr
Abstract:
Cumulative evidence indicates that the serotonin (5-HT) system plays a modulatory role in cognitive processes, particularly in learning and memory. The present review focuses on the effects of agonists and antagonists on different 5-HT receptors, administered during pre-learning, post-learning or pre-retention, in different behavioral tasks. The effects of these pharmacological compounds were either facilitative or disruptive, or allowed for recovery from impaired cognitive performance following the activation or blockade of 5-HT1, 5-HT2, 5-HT3 and 5-HT4 receptors. Since little or no data on learning and memory are currently available for the 5-ht5, 5-ht6 and 5-HT7 receptors, this article presents an overview of their brain locations and possible involvement in these highly cognitive processes.
Related Concept Videos
Role of Neurotransmitters in Memory
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...
Higher Mental Functions of Brain: Learning and Memory
Role of Amygdala in Memory
One of the...
Role of Hippocampus in Memory
Long-term Potentiation
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
