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Related Concept Videos

Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
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Production of Antibiotics

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Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
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Acute Pyelonephritis II: Diagnostic Studies and Management

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Related Experiment Video

Updated: Jul 5, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Biapenem American Cyanamid Co.

S L Dax1

  • 1R W Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, R-439, Spring House, PA 19477-0776, USA. SDax@prius.jnj.com

Idrugs : the Investigational Drugs Journal
|May 10, 2008
PubMed
Summary
This summary is machine-generated.

Biapenem is a broad-spectrum injectable carbapenem antibiotic. It is currently undergoing Phase III trials for skin infections in multiple countries and Phase I trials in the UK and US.

Related Experiment Videos

Last Updated: Jul 5, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Area of Science:

  • Pharmacology
  • Microbiology
  • Clinical Trials

Background:

  • Biapenem is an injectable carbapenem antibiotic.
  • It exhibits broad-spectrum activity against various bacteria.
  • Lederle Japan, a joint venture between Cyanamid and Takeda, has submitted Biapenem for marketing approval in Japan.

Purpose of the Study:

  • To evaluate the efficacy and safety of Biapenem.
  • To assess Biapenem's potential for treating bacterial infections.

Main Methods:

  • Biapenem is undergoing Phase III clinical trials for skin infections.
  • Phase I trials are being conducted in the UK and US.
  • The trials involve participants in Germany, South Africa, Spain, Australia, and New Zealand.

Main Results:

  • Biapenem demonstrates broad-spectrum antibacterial activity.
  • Clinical trials are progressing through Phase I and Phase III stages.

Conclusions:

  • Biapenem shows promise as a broad-spectrum antibiotic.
  • Further clinical evaluation is ongoing for various indications and geographical regions.