Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Operons

Operons

Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related protein-coding genes. Operons use a single promoter sequence to initiate transcription of a gene cluster (i.e., a group of structural genes) into a single mRNA molecule. The terminator sequence ends transcription. An operator sequence, located between the promoter and structural genes, prohibits the operon’s transcriptional activity if bound by a repressor...

Prescription, Nonprescription and Orphan Drugs

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...

Drug Regulation

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...

Transgenic Organisms

Transgenic Organisms

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A high salt diet inhibits obesity and delays puberty in the female rat.

International journal of obesity (2005)·2017

Same author

Predominant suppression of follicle-stimulating hormone β-immunoreactivity after long-term treatment of intact and castrate adult male rats with the gonadotrophin-releasing hormone agonist deslorelin.

Journal of neuroendocrinology·2011

Same author

Immunocytochemical identification of oestrogen receptors in the ovine pars tuberalis: localization within gonadotrophs.

Journal of neuroendocrinology·2011

Same author

The heart: a novel gonadotrophin-releasing hormone target.

Journal of neuroendocrinology·2011

Same author

Effects of gonadotrophin-releasing hormone outside the hypothalamic-pituitary-reproductive axis.

Journal of neuroendocrinology·2009

Same author

Oestrogen receptor beta-immunoreactive neurones in the ovine hypothalamus: distribution and colocalisation with gonadotropin-releasing hormone.

Journal of neuroendocrinology·2005

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Org-31806 Organon NV.

¹Unite Neuroendocrinologie Sexuelle, Station Physiologie de Reproduction, Institut National de la Recherche Agronomique, F-37380 Nouzilly, France. skinner@tours.inra.fr

Idrugs : the Investigational Drugs Journal

|May 10, 2008

Summary

Org-31806 is a progestogen antagonist drug being developed for cancer and menstruation disorders. This compound shows promise for treating hormone-related conditions.

Area of Science:

Pharmacology
Oncology
Gynecology

Background:

Progestogens play a role in various physiological processes and diseases.
Progestogen antagonists offer a therapeutic strategy for hormone-dependent conditions.

Purpose of the Study:

To introduce Org-31806, a novel progestogen antagonist.
To highlight its potential therapeutic applications in oncology and gynecology.

Main Methods:

Drug development pipeline analysis.
Review of preclinical and clinical data (if available).

Main Results:

Org-31806 is under development by Organon.
Demonstrates potential in preclinical models for cancer and menstruation disorders.

More Related Videos

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells

Published on: November 20, 2017

Related Experiment Videos

Last Updated: Jul 5, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells

Published on: November 20, 2017

Conclusions:

Org-31806 represents a promising therapeutic candidate.
Further research is warranted to establish its efficacy and safety profile.