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Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
Published on: January 20, 2015
SB-204269 SmithKline Beecham
1Glaxo Wellcome SpA, Pharmacology Department, Via Fleming 4, 37100 Verona, Italy. FC20377@ggr.co.uk
Abstract:
SB-204269 is an anticonvulsant agent under development by SmithKline Beecham, It is in phase II clinical trials as a potential treatment for epilepsy [243338]. The compound is structurally-related to the benzopyran ATP-sensitive potassium channel (KATP) opener, cromakalim, but has opposite stereochemistry. No KATP activators, however, show significant affinity for the binding site of SB-204269 and the mechanism of action of the latter is not thought to involve KATP. SB-204268, the opposite enantiomer, shows no anticonvulsant activity [226615]. SB concludes that SB-204269 represents a mechanistically novel anticonvulsant agent.
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