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Dopamine 98. 22-25 July 1998, Strasbourg, France.

K Drescher1, G Gross

  • 1Knoll AG, PO Box 21 08 05, D-67008 Ludwigshafen/Rhein, Germany.

Idrugs : the Investigational Drugs Journal
|May 10, 2008
PubMed
Summary
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Dopamine (DA) research focuses on central nervous system (CNS) disorders like Parkinson's disease. New selective drugs and knockout mice are advancing the understanding of DA receptor functions.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Dopamine (DA) is a neurotransmitter crucial for cognitive and emotional functions.
  • DA is implicated in CNS disorders such as schizophrenia, Parkinson's disease, and drug abuse.
  • The Dopamine Symposia have historically advanced DA research.

Purpose of the Study:

  • To review current knowledge on the physiological and pathophysiological functions of dopaminergic systems.
  • To highlight progress in basic DA research and drug development.
  • To identify emerging tools for studying dopamine receptor functions.

Main Methods:

  • Symposium presentations and posters covering CNS effects of DA.
  • Focus on advancements in understanding dopamine receptor subtypes.
  • Utilizing new pharmacological tools and genetic models.

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Main Results:

  • The symposium primarily focused on central nervous system (CNS) effects of dopamine.
  • Significant progress has been made in developing subtype-selective antagonists for DA D3 and D4 receptors.
  • The creation of knockout mice for DA transporters and receptors provides new research avenues.

Conclusions:

  • Current research emphasizes the CNS roles of dopamine.
  • Advancements in selective antagonists and genetic models are crucial for elucidating dopamine receptor functions.
  • Future research directions are geared towards understanding DA's role in neurological and psychiatric disorders.