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Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro

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Abeles symposium.

J V Schloss¹

¹Department of Medicinal Chemistry, University of Kansas, 4070 Malott Hall, Lawrence, KS 66045, USA. schloss@kuhub.cc.ukans.edu

Idrugs : the Investigational Drugs Journal

|May 10, 2008

Summary

This summary is machine-generated.

This symposium honored Robert H Abeles, a pioneer in rational drug design and suicide substrates. His work on reaction-intermediate analogs significantly impacted pharmaceutical development and enzyme mechanism studies.

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Area of Science:

Biochemistry
Medicinal Chemistry
Enzyme Kinetics

Background:

Robert H Abeles's career spans rational drug design, suicide substrates, and enzyme mechanisms.
His research on transition-state analogs, like trifluoromethyl ketones, influenced novel pharmaceutical development.
Abeles also explored unusual biosynthetic pathways and enzyme-catalyzed reactions with a strong chemical focus.

Purpose of the Study:

To celebrate and highlight the significant contributions of Professor Robert H Abeles to medicinal chemistry and biochemistry.
To provide an overview of Abeles's diverse research areas, including his foundational work on ribonucleotide reductase.
To showcase the impact of his work through presentations by former associates and colleagues.

Main Methods:

Symposium presentations by former associates and colleagues.
Oral presentations covering various research areas of Professor Abeles.
An introductory talk by Professor Joanne Stubbe detailing Abeles's career and influence.

Main Results:

Demonstrated the profound and lasting impact of Robert H Abeles's work on drug design and mechanistic enzymology.
Highlighted the breadth of his contributions, from suicide substrates to combinatorial chemistry.
Showcased the inspiration he provided to a global community of scientists.

Conclusions:

Robert H Abeles's pioneering research in rational drug design and enzyme mechanisms has had a substantial impact on pharmaceutical science.
His innovative approaches, including the use of reaction-intermediate analogs, continue to influence drug discovery.
The symposium served as a testament to his legacy and mentorship in the scientific community.