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Published on: March 11, 2017
AD-5423 Dainippon Pharmaceutical Co Ltd
Idrugs : the Investigational Drugs Journal
|May 10, 2008
Summary
AD-5423, a D(2)/5-HT2 antagonist, is well-tolerated in healthy volunteers and shows no extrapyramidal side effects. This antipsychotic drug is being developed for schizophrenia and other psychoses.
Area of Science:
- Pharmacology
- Neuroscience
- Clinical Trials
Background:
- Schizophrenia and related psychoses are significant public health challenges.
- Novel therapeutic agents targeting dopamine D(2) and serotonin 5-HT2 receptors are under investigation.
- AD-5423 is an investigational drug with combined D(2)/5-HT2 antagonist properties.
Purpose of the Study:
- To evaluate the safety and tolerability of AD-5423 in a phase I clinical trial.
- To assess potential adverse effects, including extrapyramidal symptoms, sedation, and hypotension.
Main Methods:
- A phase I clinical study was conducted in eight healthy volunteers.
- Administration of AD-5423 and monitoring for adverse events.
Main Results:
- AD-5423 was found to be well-tolerated in the study participants.
- No significant extrapyramidal side effects, excessive sedation, or hypotension were observed.
Conclusions:
- AD-5423 demonstrates a favorable safety profile in healthy volunteers.
- These findings support further investigation of AD-5423 in phase II trials for schizophrenia and psychoses.
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