[Vascular risk factors in patients with ischaemic stroke. Distribution according to age, sex and stroke subtype]
V P Moreno1, A García-Raso, M J García-Bueno
1Fundacion Jimenez Diaz, 28040 Madrid, España.
Insights
Modifiable vascular risk factors for ischaemic stroke have an additive effect and vary by stroke subtype, age, and sex. Understanding these patterns aids in predicting and preventing cardiovascular disease events.
Area of Science:
- Epidemiology
- Neurology
- Public Health
Context:
- Cardiovascular diseases are a leading cause of mortality globally.
- Ischaemic cerebrovascular disease constitutes 80% of all cerebrovascular diseases.
- Identifying modifiable risk factors is crucial for clinical intervention.
Purpose:
- To analyze the prevalence and combinations of modifiable vascular risk factors in Spanish ischaemic stroke patients.
- To investigate differences in risk factor distribution based on stroke subtype (TOAST classification), age, and sex.
Summary:
- A case-control study involving 308 ischaemic stroke patients and 307 controls was conducted.
- Results indicate an additive effect of risk factors and distinct profiles for different stroke subtypes.
- The distribution of modifiable risk factors varies significantly with stroke type, patient age, and sex.
Impact:
- Findings highlight the cumulative impact of cardiovascular risk factors on vascular events.
- This research provides insights for targeted prevention strategies in cerebrovascular disease.
- Understanding risk factor heterogeneity can improve stroke subtyping and patient management.
Introduction:
Cardiovascular diseases are one of the leading health problems in developed countries. This term covers conditions such as coronary vascular disease, cerebrovascular diseases and peripheral vascular disease. Ischaemic cerebrovascular disease accounts for 80% of all cerebrovascular diseases. From a clinical point of view it is interesting to distinguish between modifiable and non-modifiable vascular risk factors.
Aim:
To analyse the prevalence of modifiable vascular risk factors and their different combinations in a case-control study on ischaemic cerebrovascular disease in the Spanish population, and also the differences in the distribution of the risk factors according to the type of stroke (TOAST classification), age and sex.
Subjects And Methods:
The study was conducted on 308 patients with ischaemic stroke who were paired by age (+/- 5 years) and sex, with 307 controls with no prior history of thrombosis. The statistical analysis was performed using the software application SAS v. 9.1.
Results:
The results suggest that the risk factors are subject to an adding effect, as well as pointing to the presence of a specific profile of these factors depending on the subtype of stroke that is developed.
Conclusion:
The addition of cardiovascular risk factors is associated with an increased risk of vascular events. The distribution of the modifiable vascular risk factors differs according to the type of stroke and the patient's sex and age.
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