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Macular involvement in secondary systemic amyloidosis

U E Altiparmak1, B Koklu, N Unlu

  • 1Department of Ophthalmology, Ankara Training and Research Hospital, Ankara - Turkey. ealtiparmak@hotmail.com

European Journal of Ophthalmology
|May 10, 2008
PubMed
Abstract

Insights

A patient with familial Mediterranean fever experienced vision loss due to amyloidosis-related eye hemorrhages. Macular deposits persisted after hemorrhages resolved, highlighting an uncommon manifestation of this condition.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Genetics

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
  • Systemic amyloidosis can be a serious complication of FMF.
  • Ocular manifestations of amyloidosis are rare but can impact vision.

Observation:

  • A case of a 30-year-old woman with FMF-associated secondary systemic amyloidosis.
  • The patient presented with painless visual loss in the right eye.
  • Funduscopic examination revealed subretinal and preretinal hemorrhages and macular amyloid deposits.

Findings:

  • The patient experienced painless vision loss attributed to subretinal and preretinal hemorrhages.
  • Macular examination showed significant deposits, presumed to be amyloid.
  • Hemorrhages resolved within six months, but the macular deposits remained.

Implications:

  • Macular deposition and hemorrhage represent an unusual presentation of FMF-related amyloidosis.
  • Further research is needed to elucidate the nature of these deposits.
  • Understanding these ocular findings may improve FMF and amyloidosis management.

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