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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Macular involvement in secondary systemic amyloidosis
U E Altiparmak1, B Koklu, N Unlu
1Department of Ophthalmology, Ankara Training and Research Hospital, Ankara - Turkey. ealtiparmak@hotmail.com
European Journal of Ophthalmology
|May 10, 2008
Summary
A patient with familial Mediterranean fever experienced vision loss due to amyloidosis-related eye hemorrhages. Macular deposits persisted after hemorrhages resolved, highlighting an uncommon manifestation of this condition.
Area of Science:
- Ophthalmology
- Rheumatology
- Genetics
Background:
- Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
- Systemic amyloidosis can be a serious complication of FMF.
- Ocular manifestations of amyloidosis are rare but can impact vision.
Observation:
- A case of a 30-year-old woman with FMF-associated secondary systemic amyloidosis.
- The patient presented with painless visual loss in the right eye.
- Funduscopic examination revealed subretinal and preretinal hemorrhages and macular amyloid deposits.
Findings:
- The patient experienced painless vision loss attributed to subretinal and preretinal hemorrhages.
- Macular examination showed significant deposits, presumed to be amyloid.
- Hemorrhages resolved within six months, but the macular deposits remained.
Implications:
- Macular deposition and hemorrhage represent an unusual presentation of FMF-related amyloidosis.
- Further research is needed to elucidate the nature of these deposits.
- Understanding these ocular findings may improve FMF and amyloidosis management.
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