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Updated: Jul 5, 2026

Rapid Glyco-Qualitative Assessment of Recombinant Proteins Using a Fully Automated System
Published on: June 28, 2024
"Click" saccharide/beta-lactam hybrids for lectin inhibition
Claudio Palomo1, Jesus M Aizpurua, Eva Balentová
1Departamento de Química Orgánica-I, Universidad del País Vasco, Joxe Mari Korta R& D Center, San Sebastián, Spain.
Abstract:
Hybrid glycopeptide beta-lactam mimetics designed to bind lectins or carbohydrate recognition domains in selectins have been prepared according to a "shape-modulating linker" design. This approach was implemented using the azide-alkyne "click" cycloaddition reaction, and as shown by NMR/MD experiments, binding of the resulting mimetics to Ulex Europaeus Lectin-1 (UEL-1) occurred after a "bent-to-extended" conformational change around a partially rotatable triazolylmethylene moiety.

