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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Related Experiment Video

Updated: Jul 5, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Abdominal aortic calcification, BMD, and bone microstructure: a population-based study.

John T Chow1, Sundeep Khosla, L Joseph Melton

  • 1Division of Endocrinology & Metabolism, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|May 10, 2008
PubMed
Summary
This summary is machine-generated.

Vascular calcification is linked to bone density changes, particularly in older men, suggesting a shared cause for arterial and bone structure issues. Sex-specific differences were observed.

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Area of Science:

  • Gerontology
  • Bone Biology
  • Cardiovascular Health

Background:

  • Vascular calcification and bone metabolism are increasingly recognized as interconnected processes.
  • Understanding their relationship is crucial for managing age-related diseases.

Purpose of the Study:

  • To investigate the association between abdominal aortic calcification (AAC) and bone mass/structure.
  • To explore age- and sex-specific differences in this relationship.

Main Methods:

  • Assessed AAC, bone mineral density (BMD), and bone microstructure in 693 residents using QCT and HRpQCT.
  • Analyzed correlations adjusted for age, BMI, and smoking status.

Main Results:

  • AAC correlated with lower BMD in men and women, but this association diminished after adjustments.
  • In older men, AAC was linked to lower bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N), and higher trabecular separation (Tb.Sp), even after multivariable adjustment.
  • Sex-specific differences in bone microstructural associations with AAC were observed.

Conclusions:

  • An age-dependent association exists between abdominal aortic calcification and bone mineral density.
  • Specific bone microstructural parameters correlate with AAC in older men, suggesting a potential common pathogenesis.
  • The relationship between vascular calcification and bone structure exhibits sex-specific variations.