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Cerebral granular cell tumor.

Dakeun Lee1, Yeon-Lim Suh, Do H Nam

  • 1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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|May 10, 2008
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Summary
This summary is machine-generated.

Intracerebral granular cell tumors (GCTs) are rare brain tumors. This case highlights a unique cerebral GCT with extensive immunohistochemical expression and a "targetoid" appearance, suggesting glial origins.

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Area of Science:

  • Neuropathology
  • Neuro-oncology
  • Histopathology

Background:

  • Intracerebral granular cell tumors (GCTs) are exceptionally rare neoplasms.
  • Cerebral GCTs present diagnostic challenges due to their infrequent occurrence and varied histological features.

Observation:

  • A 47-year-old male presented with severe headache, found to have a cerebral GCT in the left occipital lobe.
  • Histological examination revealed a tumor composed exclusively of granular cells, some exhibiting a distinctive "targetoid" morphology.
  • The tumor cells displayed broad immunohistochemical positivity for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD68, lysozyme, and alpha-1-antitrypsin.

Findings:

  • This case demonstrated an unusually wide spectrum of immunophenotypic expression compared to previously reported cerebral GCTs.
  • Unique "targetoid" or "reversed targetoid" staining patterns were observed for NSE, CD68, GFAP, and vimentin.
  • Despite extensive and varied immunoexpressions, the tumor lacked association with astrocytoma.

Implications:

  • The findings suggest a potential glial origin for cerebral GCTs, supported by tumor location, GFAP positivity, and ultrastructural evidence of intermediate filaments resembling neoplastic astrocytes.
  • This case expands the understanding of GCT immunophenotypic variability and contributes to the ongoing discussion of their histogenesis.